NanoCare: Silver nanoparticles – mode of action and research into their possible interaction with tissues, cells and molecules
- aap biomaterials GmbH, Obernburg-Dieburg
- Justus-Liebig-Universität Gießen, Gießen
- Rent-a-scientist GmbH, Regensburg
- Universität Duisburg-Essen, Duisburg
Description of the sub-project (eXcorLab GmbH):
The main goal of the subproject is to characterize the interaction of silver nanoparticles with biological systems. We are focussed on the interaction with blood cells, vascular and skin cells.
Our first approach was to establish appropriate test systems to determine the cytotoxicity of silver nanoparticles for cultered human primary cells. In different bioassays sterility and pyrogenic behaviour of the newly developed nanoproducts was tested after contact with human donor blood. Another objective was to investigate the possible influence of silver nanoparticles on irritation and wound healing processes with the aid of an in vitro skin model. One main aspect during the development of the various test systems was the ability to discriminate between the effect of the applied silver nanoparticles and metallic silver and silver ions.
To ensure that our tests meet the requirements of our customers, we have established a quality system that fulfils all the requirements of DIN EN ISO/IEC 17025:2018 and ensures the implementation of our quality policy. This makes us an accredited testing and research institute in the areas mentioned. Our accreditation is valid in around 46 countries worldwide (including the EU, the USA and Japan), as a mutual recognition agreement, known as the ILAC Arrangement, applies between the laboratory accreditation bodies of these countries.