MOST: Development of membranes showing improved characteristics in chronic hemodialysis and improved lifetime in intensive medical care
- Leibniz-Institut für Polymerforschung Dresden e.V. /Max-Bergmann-Zentrum für Biomaterialien
- Charité Universitätsmedizin Berlin, Medizinische Klinik IV, AG experimentelle Nephrologie und Hypertensiologie
- Membrana GmbH, Wuppertal
Description of the project:
On the basis of existing (established) polymer membranes manufactured from polyethersulfon (PES) and polyvinylpyrrolidone (PVP) novel molecular and bio-mimetic technologies of functionalization of this membrane system shall be developed which allow the directed tuning of separation characteristics and biocompatibility parameters. Working packages will focus to distinctly and systematically vary the features of the PES/PVP membranes which are important for separation behaviour (performance) and the specific and non-specific interaction of molecular and cellular blood components. The resulting membrane samples will be intensively characterized with respect to physico-chemical (surface) parameters and the interaction with biopolymers and cells.
Finally it shall be possible to develop membranes which allow significantly improved blood purification and showing improved lifetime with minimal activation of the patients clotting system over a period of 24 hours. The intended properties will considerably improve the qualification of the resulting membranes for applications in intensive care medicine (acute dialysis). Particularly, the advanced purification capacity will result in the removal of hydrophobic substances that up to now could not be removed adequately. The latter feature shall improve the situation of chronic patients with cardio-vascular complications.
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